Testing Status of Crotonaldehyde 10252-S
CASRN: 4170-30-3
Formula: C4-H6-O
Synonyms/Common Names
- 2-Butenal
Short-Term Toxicity
- 14-Day (Gavage)
(C56279B)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C56279B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: M: 0, 2.5, 40 MG/KG/10 PER GROUP.
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0069)
Completed
- Male Rats
- Dose: IV: 3 MG/KG PO: 0.7, 3, 35 MG/KG.
Genetic Toxicology
- Drosophila
(854224)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Positive
- In Vitro Cytogenetics (CA/SCE)
(497791)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(A99101)
Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(097471)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
Organ Systems Toxicity
- males: 1 day until necropsy (71 to 72 days) females: 31 days until necropsy (pospartum 5 days: pregnant and 99 day: non-pregnant) Continuous Breeding (Legacy) (Gavage)
(RACB87001)
Completed
- Male and Female Rats: F344/N
- Dose: 0, 2.5, 5, OR 10 MG/KG.
- Immunotoxicity (Topical Application)
(IMM88035)
Completed
- Female Mice: B6C3F1
- Dose: 0, 0.3, 1.0, 3.0 % FOR SENSITIZATION; 10% FOR CHALLENGE; DNFB (0.5%) AS POSITIVECONTROL..