Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 1,3-Diphenylguanidine 10257-L

 

CASRN: 102-06-7

Formula: C13-H13-N3

Synonyms/Common Names

  • DPG
  • Melaniline
  • N,N'-Diphenylguanidine
  • sym-Diphenylguanidine
  • Vulkazit

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C88003)  Completed 
    • TOX-42 (NIH Number: 95-3933)
      Toxicity Studies of 1,3-Diphenylguanidine Administered in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 250, 500, 750, 1500, 3000 PPM / 5 PER GROUP.
  • 13 weeks (Dosed-Feed)  (C88003)  Completed 
    • TOX-42 (NIH Number: 95-3933)  (Tox Peer Review 03/00/1994A )
      Toxicity Studies of 1,3-Diphenylguanidine Administered in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 250, 500, 750, 1500, 3000 PPM / 10 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0026)  Completed 
    • Citation: Ioannou YM, Matthews HB. Absorption, distribution, metabolism, and excretion of 1,3-diphenylguanidine in the male F344 rat. Fundam Appl Toxicol. 1984 Feb;4(1):22-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.32, 3.2, 32 mg/kg. 3.2 mg/kg.
  • Absorption Distribution Metabolism Excretion (Topical Application)  (S0448)  Completed 
    • Citation: Shah PV, Sumler MR, Ioannou YM, Fisher HL, Hall LL. Dermal absorption and disposition of 1,3-diphenylguanidine in rats. J Toxicol Environ Health. 1985;15(5):623-33.Pubmed Abstract
    • Female Rats: Sprague Dawley
    • Dose: 0.3 umol.

Genetic Toxicology

  • Micronucleus  (A66598)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (105823)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive