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Testing Status of 2-Hydroxy-4-methoxybenzophenone 10260-S

 

CASRN: 131-57-7

Formula: C14-H12-O3

Synonyms/Common Names

  • Benzophenone 3
  • Escalol 567
  • HMB
  • (2-Hydroxy-4-methoxyphenyl)phenylmethanone
  • 4-Methoxy-2-hydroxybenzophenone
  • MOB
  • Oxybenzone
  • Sunscreen UV 15

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C60957A)  Completed 
    • TOX-21 (NIH Number: 92-3344)  (Peer Review Approval 11/21/1991A )
      Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
  • 2 weeks (Topical Application)  (C60957B)  Completed 
    • TOX-21 (NIH Number: 92-3344)  (Peer Review Approval 11/21/1991A )
      Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Topical Application)  (C60957C)  Completed 
    • TOX-21 (NIH Number: 92-3344)  (Peer Review Approval 11/00/1991A )
      Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C60957A)  Completed 
    • TOX-21 (NIH Number: 92-3344)
      Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, 3125, 6250, 12500, 25000, 50000PPM.
  • 13 weeks (Topical Application)  (C60957B)  Completed 
    • TOX-21 (NIH Number: 92-3344)
      Toxicity Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered Topically and in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0, 12.5, 25, 50, 100, 200; M:0, 22.75, 45.5, 91, 182, 364 MG/KG.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C10260)  Report in Preparation 
    • TR-597
      Toxicology and Carcinogenesis Studies of 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R&M: 0, 1000, 3000, or 10000 ppm; R: 60/sex/dose @ 0 or 10000 and 50/sex/dose @ 1000 or 3000, M: 50/sex/dose.

Modified One-Generation

  • Gestation day 6 to postnatal day 28 Dose Range Finding (Dosed-Feed)  (MOG002)  Report in Preparation 
    • Female Rats: Harlan Sprague-Dawley
  • Developmental Toxicity (Dosed-Feed)  (MOG002B)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 3000, 10000, or 30000 ppm.
  • F0 Generation (Dosed-Feed)  (MOG002B)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 3000, 10000, or 30000 ppm.
  • Fertility Assessment (Dosed-Feed)  (MOG002B)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 3000, 10000, or 30000 ppm.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dermal; Gavage)  (K10260)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1; Male and Female Rats: Sprague Dawley; Male and Female Mice: B6C3F1
    • Dose: 0.1, 10 mg/kg. 10, 100, 500 mg/kg.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0073)  Completed 
    • Male Rats: F344/N
  • 3 days Hershberger Assay (Gavage)  (K10260C)  Completed 
    • Male Rats: Harlan Sprague-Dawley
    • Dose: 0, 100, 320, 1000 mg/kg.
  • Toxicokinetic Study (Dosed-Feed; Gavage; Intravenous)  (S0593)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: Rats (iv) 8 mg/kg; (gavage) 8, 80 mg/kg; (feed) 1000, 10000 ppm Mice (iv) 50 mg/kg; (gavage) 50, 500 mg/kg; (feed) 1000, 10000 ppm.
  • 3 days Uterotrophic Assay (Gavage)  (K10260B)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 300, 1000 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (059393)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A48127)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (381877)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Weakly Positive 
  • Salmonella  (613844)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella (SA)  (G10260)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to GD 15 Developmental Toxicity (Dosed-Feed)  (R10260B)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 3K, 10K or 30K ppm and 0.05 ppm ethinyl estradiol; 25/sex/dose.
  • GD 6 to GD 15 Developmental Toxicity (Dosed-Feed)  (R10260C)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 3K, 10K or 30K ppm; 25 sex/dose.
  • GD 6 to PND 21 Developmental Toxicity (Dosed-Feed)  (R10260D)  On Test 
    • Citation: Nakamura N, Vijay V, Desai VG, Hansen DK, Han T, Chang CW, Chen YC, Harrouk W, McIntyre B, Foster PM, Fuscoe JC, Inselman AL. Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone. Reprod Toxicol. 2018 Dec;82:111-123. doi: 10.1016/j.reprotox.2018.10.001. Epub 2018 Oct 11.
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 3K, 10K or 30K ppm and 0.05 ppm ethinyl estradiol; 25/sex/dose.
  • 35 days Developmental Toxicity (Dosed-Feed)  (R10260)  Completed 
    • Citation: Nakamura N, Vijay V, Desai VG, Hansen DK, Han T, Chang CW, Chen YC, Harrouk W, McIntyre B, Foster PM, Fuscoe JC, Inselman AL. Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone. Reprod Toxicol. 2018 Dec;82:111-123. doi: 10.1016/j.reprotox.2018.10.001. Epub 2018 Oct 11.
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 1K, 3K, 10K, 25K and 50K ppm.
  • Immunotoxicity Selected (I10260)  
    • Male and Female Rats: Harlan Sprague-Dawley
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88076)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, 1.25, 2.5, 5%; 0, .3125, .625, 1.25, 2.5, 5%; 0, 5%; .

Toxicogenomics

  • 13 weeks Microarray Analysis (Dosed-Feed)  (T10260)  Completed 
    • Rats: Harlan Sprague-Dawley

in vitro Testing

  • Androgen Receptor Binding Assay (Whole Body Exposure)  (V10260B)  Completed 
    • Androgen Receptor Binding Assay
    • Rats: Sprague Dawley
  • Estrogen Receptor Binding Assay (Whole Body Exposure)  (V10260C)  Completed 
    • Estrogen Receptor Binding Assay
    • Rats: Sprague Dawley
  • Androgen Receptor Transactivation Assay (Whole Body Exposure)  (V10260D)  Completed 
    • Androgen Receptor Transactivation Assay
    • Human (Cell Lines)
  • Estrogen Receptor Transactivation Assay  (V10260E)  Completed 
    • Estrogen Receptor Transactivation Assay
    • Human (Cell Lines)
  • Human Recombinant Aromatase Assay  (V10260G)  Completed 
    • Human Recombinant Aromatase Assay
    • Human (Cell Lines)
  • H295R Steroidogenesis Assay (Whole Body Exposure)  (V10260)  Completed 
    • H295R Steroidogenesis Assay
    • Human (Cell Lines)