Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Isoeugenol 10262-A

 

CASRN: 97-54-1

Formula: C10-H12-O2

Synonyms/Common Names

  • 2-Methoxy-4-(1-propenyl)-phenol (9CI)

Short-Term Toxicity

  • 13 weeks (Gavage)  (C88105)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 37.5, 75, 150, 300, OR 600 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C88105)  Completed 
    • TR-551 (NIH Number: 10-5892)  (Peer Review Approval 02/27/2008A )
      NTP Toxicology and Carcinogenesis Studies of Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1 Mice (Gavage studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0, 75, 150, OR 300 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0845)  Completed 
    • Citation: Badger DA, Smith RL, Bao J, Kuester RK, Sipes IG. Disposition and metabolism of isoeugenol in the male Fischer 344 rat. Food Chem Toxicol. 2002 Dec;40(12):1757-65.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 15.6 mg/kg, 120 uCi/kg. 156 mg/kg, 50 uCi/kg.
  • Metabolism (in-vitro)  (S0657)  Completed 
    • Citation: Burkey JL, Sauer JM, McQueen CA, Sipes IG. Cytotoxicity and genotoxicity of methyleugenol and related congeners- a mechanism of activation for methyleugenol. Mutat Res. 2000 Sep 20;453(1):25-33.Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1; Human (Cell Lines)
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K10262)  Completed 
    • Citation: Hong SP, Fuciarelli AF, Johnson JD, Graves SW, Bates DJ, Smith CS, Waidyanatha S. Toxicokinetics of isoeugenol in F344 rats and B6C3F1 mice. Xenobiotica. 2013 Nov;43(11):1010-7. doi: 10.3109/00498254.2013.790576. Epub 2013 Apr 29.Pubmed Abstract
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 17 mg/kg. 0, 17, 70, 140 mg/kg. 0, 35 mg/kg. 0, 35, 70, 140 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A00394)  Completed 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A67394)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Salmonella  (298252)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (A66240)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Gavage)  (RACB97004)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 70, 230, 700 mg/kg/day (Gavage).
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER97006)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 250, 500, OR 1000 MG/KG/DAY.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP92041)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 200, 400, 600, OR 800 MG/KG.
  • Teratology Pilot Studies (Gavage)  (TRP92042)  Completed 
    • Rabbits: New Zealand White
    • Dose: 0, 50, 100, 200, 400, 600 MG/KG/DAY.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP97006)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 200, 400, 600, 800, OR 1000 MG/KG/DAY.