Testing Status of Methyleugenol 10265-L
CASRN: 93-15-2
Formula: C11-H14-O2
Synonyms/Common Names
- 1,2-Dimethoxy-4-(2-propenyl)benzene
Short-Term Toxicity
- 5 days (Gavage)
(C10265)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley
- Dose: Male rats: 0, 4.625, 9.25, 18.5, 37, 75, 150, 300, or 600 mg/kg; N=4.
- 2 weeks (Gavage)
(C60991)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 10000, 20000 AND 40000 PPM/ RATS: 10 MALE, 5 FEMALE/GROUP; MICE: 5/SEX/GROUP.
- 13 weeks (Gavage)
(C60991)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 10, 30, 100, 300, 1000 MG/KG PLUS SHAM GAVAGE GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C60991B)
Completed
- TR-491 (NIH Number: 00-3950)
(Peer Review Approval 10/30/1998A )
Toxicology and Carcinogenesis Studies of Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R&M: 0, 37, 75, OR 150 MG/KG; 50/SEX/SPECIES/GROUP.
- TR-491 (NIH Number: 00-3950)
(Peer Review Approval 10/30/1998A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0844)
Completed
- Male Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N
- Dose: 118 mg/kg, 50 uCi/kg gavage; 11.8 mg/kg, 120 uCi/kg intravenously; 118 mg/kg, 50 uCi/kg gavage.
- Metabolism (in-vitro)
(S0658)
Completed
- Citation: Burkey JL, Sauer JM, McQueen CA, Sipes IG. Cytotoxicity and genotoxicity of methyleugenol and related congeners- a mechanism of activation for methyleugenol. Mutat Res. 2000 Sep 20;453(1):25-33.Pubmed Abstract
- Male and Female Rats; Male and Female Mice; Male and Female Human (Cell Lines)
- Metabolism (in-vitro)
(S0898)
Completed
- Male Rats: F344/N; Female Mice: B6C3F1; Human (Cell Lines)
- Other (in-vitro)
(S0826)
Completed
- Citation: Burkey JL, Sauer JM, McQueen CA, Sipes IG. Cytotoxicity and genotoxicity of methyleugenol and related congeners- a mechanism of activation for methyleugenol. Mutat Res. 2000 Sep 20;453(1):25-33.Pubmed Abstract
- Male Rats: Fischer 344; Mice: B6C3F1
- Toxicokinetic Study (Gavage; Intravenous)
(K10265)
Completed
- Citation: Hong SP, Fuciarelli AF, Johnson JD, Graves SW, Bates DJ, Waidyanatha S, Smith CS. Toxicokinetics of methyleugenol in F344 rats and B6C3F1 mice. Xenobiotica. 2013 Mar;43(3):293-302. doi: 10.3109/00498254.2012.711496. Epub 2012 Aug 10.Pubmed Abstract
- Rats: Fischer 344; Mice: B6C3F1; Rats: F344/N; Mice: B6C3F1
- Toxicokinetic Study (Gavage)
(S0577)
Completed
- Citation: Graves SW, Runyon S. Determination of methyleugenol in rodent plasma by high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 663(2):255-62. doi: 10.1016/0378-4347(94)00452-B.Pubmed Abstract
- Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(614248)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Micronucleus
(A29699)
Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(690169)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- 6 to 19 GD Conventional Teratology (Gavage)
(TER97007)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 80, 200, OR 500 MG/KG/DAY.
- 6 to 15 GD Teratology Pilot Studies (Gavage)
(TRP92045)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 300, 600, 800, 1000, OR 1200 MG/KG.
- 6 to 19 GD Teratology Pilot Studies (Gavage)
(TRP92046)
Completed
- Female Rabbit: New Zealand White
- Dose: 0, 100, 400, 600, 800, OR 1000 MG/KG.
- 6 to 19 GD Teratology Pilot Studies (Gavage)
(TRP97007)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG/DAY.
Toxicogenomics
- 5 days Transcriptome Sequencing (Gavage)
(T10265)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley