Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Tricresyl Phosphate 10277-D

 

CASRN: 1330-78-5

Formula: C21-H21-O4-P

Synonyms/Common Names

  • Flame Retardant 1
  • Phosphoric acid, tris(methylphenyl)ester (9CI)
  • TCP

Short-Term Toxicity

  • 5 days (Gavage)  (C10277)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.
  • 14-Day (Gavage)  (C61041A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C61041A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 50, 800 mg/kg/10 per group.
  • 13-Week (Dosed-Feed)  (C61041B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 900, 1300, M: 0, 250, 4200 ppm/5 per group.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C61041B)  Completed 
    • TR-433 (NIH Number: 94-3164)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 75, 150, 300, 600, M: 0, 60, 125, 250 ppm/50 per group.

Special Studies

  • C. elegans  (W10277)  Completed 
    • C. elegans
    • Dose: Growth: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMRepro: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (272835)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (197511)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (618410)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84114)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .05, .1, .2%; N/A; N/A.

Toxicogenomics

  • Microarray Analysis (Gavage)  (T10277)  Completed 
    • Rats: Harlan Sprague-Dawley