Testing Status of Tricresyl Phosphate 10277-D
CASRN: 1330-78-5
Formula: C21-H21-O4-P
Synonyms/Common Names
- Flame Retardant 1
- Phosphoric acid, tris(methylphenyl)ester (9CI)
- TCP
Short-Term Toxicity
- 5 days (Gavage)
(C10277)
Completed
- Rats: Harlan Sprague-Dawley
- Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.
- 14-Day (Gavage)
(C61041A)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C61041A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 50, 800 mg/kg/10 per group.
- 13-Week (Dosed-Feed)
(C61041B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 900, 1300, M: 0, 250, 4200 ppm/5 per group.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C61041B)
Completed
- TR-433 (NIH Number: 94-3164)
(Peer Review Approval 06/22/1993A )
Toxicology and Carcinogenesis Studies of Tricresyl Phosphate in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 75, 150, 300, 600, M: 0, 60, 125, 250 ppm/50 per group.
- TR-433 (NIH Number: 94-3164)
(Peer Review Approval 06/22/1993A )
Special Studies
- C. elegans
(W10277)
Completed
- C. elegans
- Dose: Growth: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMRepro: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(272835)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Salmonella
(197511)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
- Salmonella
(618410)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Negative
Organ Systems Toxicity
- 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)
(RACB84114)
Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, .05, .1, .2%; N/A; N/A.
Toxicogenomics
- Microarray Analysis (Gavage) Selected (T10277)
- Rats: Harlan Sprague-Dawley