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Testing Status of 9-Aminoacridine hydrochloride 10278-G


CASRN: 134-50-9

Formula: C13-H10-N2.Cl-H

Synonyms/Common Names

  • 9-Acridinamine, monohydrochloride

Short-Term Toxicity

  • 14-Day (Topical Application)  (C61483A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Dosed-Feed)  (C61483B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C61483B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 150, 2400, M: 0, 37.5, 600 PPM/10 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Topical Application)  (S0116)  Completed 
    • Citation: el Dareer SM, Kalin JR, Tillery KF, Hill DL. Disposition of 9-aminoacridine in rats dosed orally or intravenously and in monkeys dosed topically. J Toxicol Environ Health. 1985;15(6):789-99.Pubmed Abstract
    • Male Rats: F344/N; Monkeys
    • Dose: 0.0226, or 0.113 mg. 0.746 g/kg. 0.802 mg/kg. 1.5, 20, 200 mg/kg. 2, 27 mg/kg.

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84042)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 0.25, 0.5, 1.25, 2.5, 2.5, 5.0%; N/A; N/A.