Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of o-Benzyl-p-chlorophenol 10283-V

 

CASRN: 120-32-1

Formula: C13-H11-Cl-O

Synonyms/Common Names

  • 4-Chloro-2-(phenylmethyl)phenol

Short-Term Toxicity

  • 14-Day (Gavage)  (C61201A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 3 weeks (Topical Application)  (C61201B)  Completed 
    • Mice: Swiss CD-1
  • 13-Week (Gavage)  (C61201A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 30, 480 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 1 year (Topical Application)  (C61201B)  Completed 
    • TR-444 (NIH Number: 95-3157)  (Peer Review Approval 11/17/1993A )
      One-Year Initiation/Promotion Study of o-Benzyl-p-Chlorophenol in Swiss (CD-1) Mice (Mouse Skin Study)
    • Mice: Swiss CD-1
    • Dose: ACETONE CONTROL, DMBA/DMBA, DMBA/ACETONE, DMBA/TPA, DMBA/BCP(1, 10, 30 MG/ML), TPA/TPA, BCP(10)/TPA, BCP/BCP, BCP(10)/BCP(1, 10, 30).
  • 2 years (Gavage)  (C61201C)  Completed 
    • TR-424 (NIH Number: 94-3155)  (Peer Review Approval 12/01/1992A )
      Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 30, 60, 120, FR: 0, 60, 120, 240, M: 0, 120, 240, 480 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous)  (S0070)  Completed 
    • Citation: Kao LR, Birnbaum LS. Disposition of o-benzyl-p-chlorophenol in male rats. J Toxicol Environ Health. 1986;18(3):441-58.Pubmed Abstract
    • Male Rats: Fischer 344
    • Dose: 10 mg/kg. 10, 100, 1000 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (353016)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (284925)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (845798)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM89037)  Completed 
    • Female Mice: B6C3F1
    • Dose: SENSITIZATION: 0, 1, 3, 10%; CHALLENGE: 30%; POSITIVE CONTROL (DNFB) 0.5%..
  • Neurotoxicology Assessment (Gavage)  (NTA94016)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N