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Testing Status of o-Benzyl-p-chlorophenol 10283-V

 

CASRN: 120-32-1

Formula: C13-H11-Cl-O

Synonyms/Common Names

  • 4-Chloro-2-(phenylmethyl)phenol

Short-Term Toxicity

  • 14-Day (Gavage)  (C61201A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 3 weeks (Topical Application)  (C61201B)  Completed 
    • Mice: Swiss CD-1
  • 13-Week (Gavage)  (C61201A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 30, 480 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 1 year (Topical Application)  (C61201B)  Completed 
    • TR-444 (NIH Number: 95-3157)  (Peer Review Approval 11/17/1993A )
      Initiation/Promotion Study ofo-Benzyl-p-Chlorophenol (CASRN120-32-1) in Swiss (CD-1®) Mice (Mouse Skin Study)
    • Mice: Swiss CD-1
    • Dose: ACETONE CONTROL, DMBA/DMBA, DMBA/ACETONE, DMBA/TPA, DMBA/BCP(1, 10, 30 MG/ML), TPA/TPA, BCP(10)/TPA, BCP/BCP, BCP(10)/BCP(1, 10, 30).
  • 2 years (Gavage)  (C61201C)  Completed 
    • TR-424 (NIH Number: 94-3155)  (Peer Review Approval 12/01/1992A )
      Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 30, 60, 120, FR: 0, 60, 120, 240, M: 0, 120, 240, 480 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0070)  Completed 
    • Citation: Kao LR, Birnbaum LS. Disposition of o-benzyl-p-chlorophenol in male rats. J Toxicol Environ Health. 1986;18(3):441-58.Pubmed Abstract
    • Male Rats: F344/N; Male Rats
    • Dose: 10, 100, 1000:GAV 10 MG/KG:IV.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (353016)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (284925)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Salmonella  (845798)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM89037)  Completed 
    • Female Mice: B6C3F1
    • Dose: SENSITIZATION: 0, 1, 3, 10%; CHALLENGE: 30%; POSITIVE CONTROL (DNFB) 0.5%..
  • Neurotoxicology Assessment (Gavage)  (NTA94016)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N