Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Tetraethylthiuram disulfide 10291-V

 

CASRN: 97-77-8

Formula: C10-H20-N2-S4

Synonyms/Common Names

  • Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl-

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C02959)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C02959)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1500, 6800, FM: 0, 250, 10000 PPM/5 PER GROUP - MM: 0, 2000, 8000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C02959)  Completed 
    • TR-166 (NIH Number: 79-1722)  (Peer Review Approval 12/13/1978A )
      Bioassay of Tetraethylthiuram Disulfide for Possible Carcinogenicity (CASRN 97-77-8)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 300, 600, MM: 0, 500, 2000, FM: 0, 100, 500 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (038371)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (768765)  Completed 
    • Sister Chromatid Exchange Not a Valid Test 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (986702)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Salmonella  (748370)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0044)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 4900 MG/KG BODY WEIGHT.