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Testing Status of Vanadium pentoxide 10306-Y

 

CASRN: 1314-62-1

Formula: O5-V2

Synonyms/Common Names

  • Vanadium oxide (9CI)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61427)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0.0, 2.0, 4.0, 8.0, 16.0 OR 32.0 MG/M3 (5/S/S).
  • 2 weeks (Inhalation)  (C61427B)  Completed 
    •   (Peer Review Approval 10/18/2001A ) Citation: Ress NB, Chou BJ, Renne RA, Dill JA, Miller RA, Roycroft JH, Hailey JR, Haseman JK, Bucher JR. Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. Toxicol Sci. 2003 Aug;74(2):287-96. https://doi.org/10.1093/toxsci/kfg136. Epub 2003 May 28.
    • Rats: F344/N; Mice: B6C3F1
    • Dose: FR: 0, 1, 2, OR 4 MG/M3 FM: 0, 2, 4, OR 8 MG/M3; 60/SPECIES/GROUP.
  • 13 weeks (Inhalation)  (C61427)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0.0, 1.0, 2.0, 4.0, 8.0, OR 16 MG/M3 (10/S/S).

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C61427B)  Completed 
    •   (Peer Review Approval 10/18/2001A ) Citation: Ress NB, Chou BJ, Renne RA, Dill JA, Miller RA, Roycroft JH, Hailey JR, Haseman JK, Bucher JR. Carcinogenicity of inhaled vanadium pentoxide in F344/N rats and B6C3F1 mice. Toxicol Sci. 2003 Aug;74(2):287-96. https://doi.org/10.1093/toxsci/kfg136. Epub 2003 May 28.
    • TR-507 (NIH Number: 03-4441)  (Peer Review Approval 10/18/2001A )
      Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 0.5, 1, OR 2 MG/M3 M: 0, 1, 2, OR 4 MG/M3; 70/SEX/SPECIES/GROUP.

Special Studies

  • Toxicokinetic Study (Inhalation)  (S0607)  Completed 
    • Citation: Dill JA, Lee KM, Mellinger KH, Bates DJ, Burka LT, Roycroft JH. Lung deposition and clearance of inhaled vanadium pentoxide in chronically exposed F344 rats and B6C3F1 mice. Toxicol Sci. 2004 Jan;77(1):6-18. https://doi.org/10.1093/toxsci/kfh005. Epub 2003 Nov 4.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 14d: FR: 1, 2, 4 mg/m3; FM: 2, 4, 8 mg/m3 (report 08/96) 104w: R: 0.5, 1, 2 mg/m3; M: 1, 2, 4 mg/m3.

Genetic Toxicology

  • Micronucleus  (A59682)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (523108)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Inhalation)  (S0001)  Completed 
    • Monkeys