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Testing Status of Methyl isobutyl ketone 10314-Y


CASRN: 108-10-1

Formula: C6-H12-O

Synonyms/Common Names

  • Hexone
  • Isopropylacetone
  • 4-Methyl-2-oxopentane
  • 4-Methyl-2-pentanone
  • MIBK

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C97006)  Completed 
    • TR-538 (NIH Number: 07-4476)  (Peer Review Approval 09/27/2005A )
      Toxicology and Carcinogenesis Studies of Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 450, 900, OR 1800 PPM.

Genetic Toxicology

  • Salmonella  (661200)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative