Testing Status of Phenylbutazone 10354-F
CASRN: 50-33-9
Formula: C19-H20-N2-O2
Synonyms/Common Names
- 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione (9CI)
Short-Term Toxicity
- 2 weeks (Gavage)
(C56531)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13 weeks (Gavage)
(C56531)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 25, 50, 100, 200, OR 300 MG/KG M: 0, 40, 80, 150, 300, OR 600 MG/KG.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C56531)
Completed
- TR-367 (NIH Number: 89-2822)
(Peer Review Approval 03/13/1989A )
Toxicology and Carcinogenesis Studies of Phenylbutazone (CASRN 50-33-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats Some Evidence
- Male Mice Some Evidence
- Female Mice No Evidence
- Dose: R: 0, 50, 100, M: 0, 150, 300 MG/KG/50 PER GROUP.
- TR-367 (NIH Number: 89-2822)
(Peer Review Approval 03/13/1989A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(534081)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Positive
- Micronucleus
(476079)
Completed
- Mice: B6C3F1
- Male Negative
- Mouse Lymphoma
(421302)
Completed
- Mice
- Positive
- Salmonella
(030078)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative