Testing Status of Reserpine 10355-J
CASRN: 50-55-5
Formula: C33-H40-N2-O9
Synonyms/Common Names
- (3beta,16beta,17alpha,18beta,20alpha)-11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-yohimban-16-carboxylic acid methyl ester
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C50157)
Completed
- Rats: F344/N; Mice: B6C3F1
- 2 weeks (Dosed-Feed)
(C50157B)
Completed
- Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk); Mice: MMTV/RAS (Tg.SH)
- Dose: 0, 2.5, 5.0, 10.0, OR 20.0 PPM.
- 13-Week (Dosed-Feed)
(C50157)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, .4, .8, 1.5, 3.0, 6.0 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C50157)
Completed
- TR-193 (NIH Number: 79-1748)
(Peer Review Approval 05/01/1979A )
Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Negative
- Male Mice Positive
- Female Mice Positive
- Dose: 0, 5, 10 PPM/50 PER GROUP.
- TR-193 (NIH Number: 79-1748)
(Peer Review Approval 05/01/1979A )
- 26 & 39 weeks (Dosed-Feed)
(C50157B)
Completed
- Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk); Mice: MMTV/RAS (Tg.SH)
- Dose: MTD AND 1/2 MTD.
Genetic Toxicology
- Chromosome Aberrations
(013797)
Completed
- Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
- Mice
- Positive
- Drosophila
(531881)
Completed
- Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
- Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal
- Drosophila
(685541)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(057864)
Completed
- Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Micronucleus
(487993)
Completed
- Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
- Mice: B6C3F1
- Male Negative
- Mouse Lymphoma
(562201)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Negative
- Salmonella
(450632)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Negative
- Salmonella
(N-9330)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Sister Chromatid Exchanges
(013797)
Completed
- Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
- Mice
- Sister Chromatid Negative