Testing Status of beta-Nitrostyrene 10363-J

CASRN: 102-96-5

Formula: C8-H7-N-O2

Synonyms/Common Names

• (2-Nitroethenyl)-Benzene (9CI)

Short-Term Toxicity

• 14-Day (Gavage)  (C02211)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C02211)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 100, 1000, M: 0, 100, 464 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C02211)  Completed 
  • TR-170 (NIH Number: 79-1726)  (Peer Review Approval 08/31/1978A )
    Bioassay of a Solution of ß-Nitrostyrene and Styrene for Possible Carcinogenicity (CASRN 102-96-5, CASRN 100-42-5)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Negative 
    • Female Rats Negative 
    • Male Mice Negative 
    • Female Mice Negative 
  • Dose: MR: 0, 150, 300, FR: 0, 75, 150, M: 0, 87.5, 175 MG/KG/50 PER GROUP.

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (640414)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Salmonella  (478054)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Weakly Positive 
• Salmonella  (486045)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative