Testing Status of Diethylstilbestrol 10364-N
CASRN: 56-53-1
Related: TRANSGENIC MODEL EVALUATION (DIETHYLSTILBESTROL)
Formula: C18-H20-O2
Synonyms/Common Names
- DES
- 4,4'-(1,2-diethyl-1,2-ethenediyl)bis-, (E)-
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(293260)
Completed
- Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Positive
- Micronucleus
(A04328)
Completed
- Mice: Tg.AC
- Male Negative
- Female Negative
- Micronucleus
(A06412)
Completed
- Mice: FVB/N
- Male Negative
- Female Negative
- Micronucleus
(A27424)
Completed
- Mice: BRCA1(+/+)
- Female Positive
- Micronucleus
(A30983)
Completed
- Mice: FVB/N
- Male Negative
- Female Negative
- Micronucleus
(A66561)
Completed
- Mice: Tg.AC
- Male Negative
- Female Negative
- Micronucleus
(A82167)
Completed
- Mice: C3H
- Female Negative
- Micronucleus
(A99812)
Completed
- Mice: BRCA1(+/-)
- Female Positive
- Mouse Lymphoma
(384132)
Completed
- Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
- Mice
- Positive
- Mouse Lymphoma
(G19656)
Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mice
- Mouse Lymphoma
(G81461)
Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mice
- Salmonella
(209298)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
- Negative
- Salmonella
(N-9091)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
Organ Systems Toxicity
- 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)
(RACB83046)
Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, 1, 10, 50 PPB; 0, 50 PPB; N/A.
- 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)
(RACB83094)
Completed
- Male and Female Mice: Swiss
- Dose: N/A; 0, 1, 10, 50 PPB; 0, 50 PPB; N/A.
- 9 to 16 GD Conventional Teratology (Subcutaneous Injection)
(TER93137)
Completed
- Female Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, 2.5, 5, 10, 50, 100 UG/KG/DAY IN CORN OIL; 0, 100 UG/KG/DAY IN TRIOCTANOIN.
- 14 days Immunotoxicity (Subcutaneous Injection)
(IMM82001)
Completed
- Female Mice: B6C3F1
- Dose: 0, 0.2, 1, 2, OR 4 MG/KG.