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Testing Status of L-Tryptophan 10395-R

 

CASRN: 73-22-3

Formula: C11-H12-N2-O2

Synonyms/Common Names

  • 1-Tryptophan (9CI)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01729)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01729)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01729)  Completed 
    • TR-071 (NIH Number: 78-1321)  (Peer Review Approval 03/07/1978A )
      Bioassay of L-Tryptophan for Possible Carcinogenicity (CASRN 73-22-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 25000, 50000 PPM/35 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (702434)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (304004)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (763523)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative