Testing Status of Bromodichloromethane 10397-Y

CASRN: 75-27-4

Formula: C-H-Br-Cl2

Synonyms/Common Names

Dichlorobromomethane

Short-Term Toxicity

14-Day (Gavage) (C55243) Completed
- Rats: F344/N; Mice: B6C3F1
13-Week (Gavage) (C55243) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 19, 300, MM: 0, 6.25, 100, FM: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

108 weeks (Gavage) (C55243) Completed
- TR-321 (NIH Number: 88-2537) (Peer Review Approval 08/19/1986A )
  Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
- Mice: B6C3F1
- Carcinogenesis Results
  - Male Rats Clear Evidence
  - Female Rats Clear Evidence
  - Male Mice Clear Evidence
  - Female Mice Clear Evidence
- Dose: R: 0, 50, 100 MM:0, 25, 50 FM: 0, 75, 150 MG/KG/50 PER GROUP.
2 years (Gavage) (C55243) Completed
- TR-321 (NIH Number: 88-2537) (Peer Review Approval 08/19/1986A )
  Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
- Rats: F344/N
- Carcinogenesis Results
  - Male Rats Clear Evidence
  - Female Rats Clear Evidence
  - Male Mice Clear Evidence
  - Female Mice Clear Evidence
- Dose: R: 0, 50, 100 MM:0, 25, 50 FM: 0, 75, 150 MG/KG/50 PER GROUP.

Special Studies

Absorption Distribution Metabolism Excretion (Gavage; Intravenous) (S0097) Completed
- Citation: Mathews JM, Troxler PS, Jeffcoat AR. Metabolism and distribution of bromodichloromethane in rats after single and multiple oral doses. J Toxicol Environ Health. 1990 May;30(1):15-22.Pubmed Abstract
- Male Rats: F344/N; Rats: F344/N
- Dose: 1, 10, 32, 100 mg/kg; 10, 100 mg/kg/day (10 day repeat).
Absorption Distribution Metabolism Excretion (Gavage) (S0527) Completed
- Male Rats: F344/N
- Dose: 1, 10, 32, 100 mg/kg.
Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous) (K05097) Completed
- Rats: Fischer 344; Mice: B6C3F1
Toxicokinetic Study (Gavage) (S0644) Completed
- Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

In Vitro Cytogenetics (CA/SCE) (494532) Completed
- Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
- Sister Chromatid Exchange Equivocal
- Chromosome Aberrations Negative
Micronucleus (A08959) Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Male Equivocal
- Female Negative
Micronucleus (A38548) Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Male Equivocal
- Female Equivocal
Micronucleus (A39408) Completed
- Mice: Tg.AC (FVB/N) Hemizygous
- Male Negative
- Female Negative
Micronucleus (A42280) Completed
- Mice: B6C3F1
- Male Negative
Micronucleus (A55870) Completed
- Mice: P53 +/- (C57BL/6)
- Male Negative
- Female Negative
Micronucleus (A78486) Completed
- Mice: B6C3F1
- Female Negative
Micronucleus (A90924) Completed
- Mice: P53 +/- (C57BL/6)
- Male Equivocal
- Female Negative
Mouse Lymphoma (173442) Completed
- Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
- Mice
- Positive
Salmonella (038604) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Salmonella (A68248) Completed
- Negative

Organ Systems Toxicity

35 days Repro/Dev Gen Tox (28-Day) (Dosed-Water) (RDGT94017) Completed
- Rats: Sprague Dawley