Testing Status of Methyl bromide 10399-G
CASRN: 74-83-9
Formula: C-H3-Br
Synonyms/Common Names
- Bromomethane (9CI)
Short-Term Toxicity
- 14-Day (Inhalation)
(C04148A)
Completed
- Mice: B6C3F1
- 6 weeks (Inhalation)
(C04148C)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Inhalation)
(C04148A)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 30, 120, M: 0, 10, 120 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C04148B)
Completed
- TR-385 (NIH Number: 92-2840)
(Peer Review Approval 11/19/1990A )
Toxicology and Carcinogenesis Studies of Methyl Bromide (CASRN 74-83-9) in B6C3F1 Mice (Inhalation Studies) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: MICE ONLY:0, 10, 33, 100 PPM.
- TR-385 (NIH Number: 92-2840)
(Peer Review Approval 11/19/1990A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage)
(S0165)
Completed
- Citation: Medinsky MA, Bond JA, Dutcher JS, Birnbaum LS. Disposition of [14C]methyl bromide in Fischer-344 rats after oral or intraperitoneal administration. Toxicology. 1984 Sep 14;32(3):187-96.Pubmed Abstract
- Male Rats: F344/N
- Dose: 250 MICROMOLES.
- Absorption Disposition Metabolism Elimination (Inhalation)
(S0335)
Completed
- Citation: Bond JA, Dutcher JS, Medinsky MA, Henderson RF, Birnbaum LS. Disposition of [14C]methyl bromide in rats after inhalation. Toxicol Appl Pharmacol. 1985 Apr;78(2):259-67. Pubmed Abstract
- Citation: Medinsky MA, Dutcher JS, Bond JA, Henderson RF, Mauderly JL, Snipes MB, Mewhinney JA, Cheng YS, Birnbaum LS. Uptake and excretion of [14C]methyl bromide as influenced by exposure concentration. Toxicol Appl Pharmacol. 1985 Apr;78(2):215-25.Pubmed Abstract
- Male Rats: F344/N
- Dose: 337 NANAMOLES/L FOR 6 HRS (1ST STUDY) 50, 300, 5700, 10, 400 NANOMOLES FOR 6 HRS (2ND STUDY).
Genetic Toxicology
- Micronucleus
(A51339)
Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Female Positive
- Salmonella
(510898)
Completed
- Positive
Organ Systems Toxicity
- 5 days/week for 3 weeks before breeding, or 1 to 19 GD, or 3 weeks before breeding plus 1 to 19 GD Conventional Teratology (Inhalation)
(T0021A)
Completed
- Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
- Female Rats: Wistar
- Dose: 20, 70 ppm 7 hr/day.
- 1 to 15 GD Conventional Teratology (Inhalation)
(T0021B)
Completed
- Citation: Teratologic Assessment of Butylene Oxide, Styrene Oxide, Methylbromide
- Female Rabbits: New Zealand White
- Dose: 20 or 70 ppm, 7 hr/day.
- Neurotoxicology Assessment (Inhalation)
(NTA94006)
Completed
- Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
- Male and Female Rats/Mice: F344/N