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Testing Status of Phthalic anhydride 10421-A

 

CASRN: 85-44-9

Formula: C8-H4-O3

Synonyms/Common Names

  • 1,3-Isobenzofurandione (9CI)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C03601)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6200, 50000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C03601)  Completed 
    • TR-159 (NIH Number: 79-1715)  (Peer Review Approval 12/13/1978A )
      Bioassay of Phthalic Anhydride for Possible Carcinogenicity (CASRN 85-44-9)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 7500, 15000, MM: 0, 16346, 32692 (AVG), FM: 0, 12019, 24038 (AVG) PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (164933)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Mouse Lymphoma  (358037)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (050139)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (648374)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative