Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Benzidine 10446-K

 

CASRN: 92-87-5

Formula: C12-H12-N2

Synonyms/Common Names

  • (1,1'-Biphenyl)-4,4'-diamine

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0083)  Completed 
    • Citation: Lynn RK, Garvie-Gould CT, Milam DF, Scott KF, Eastman CL, Ilias AM, Rodgers RM. Disposition of the aromatic amine, benzidine, in the rat: characterization of mutagenic urinary and biliary metabolites. Toxicol Appl Pharmacol. 1984 Jan;72(1):1-14.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 5 mg/kg.
  • Metabolism (in-vitro)  (S0438)  Completed 
    • Citation: Lynn RK, Garvie-Gould C, Milam DF, Scott KF, Eastman CL, Rodgers RM. Metabolism of the human carcinogen, benzidine, in the isolated perfused rat liver. Drug Metab Dispos. 1983 Mar-Apr;11(2):109-14.Pubmed Abstract
    • Male Rats: F344/N
  • Metabolism (Dosed-Feed)  (S0771)  Completed 
    • Citation: Luster MI, Tucker AN, Hayes HT, Pung OJ, Burka T, McMillan R, Eling T. Immunosuppressive effects of benzidine in mice: evidence of alterations in arachidonic acid metabolism. J Immunol. 1985 Oct;135(4):2754-61.Pubmed Abstract
    • Mice

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (993740)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella Reduction  (609278)  Completed 
    • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
    •  Positive 
  • Salmonella  (038268)  Completed 
    •  Positive 
  • Salmonella  (267901)  Completed 
    •  Positive 
  • Salmonella  (336867)  Completed 
    •  Positive 
  • Salmonella  (381549)  Completed 
    •  Positive 
  • Salmonella  (500249)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (503193)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Immunotoxicity  (IMM83004)  Completed 
    • Female Mice: B6C3F1