Testing Status of 2,4-Dichlorophenoxyacetic acid 10451-Y
CASRN: 94-75-7
Related: PEROXISOME PROJECT (2,4-DICHLOROPHENOXYACETIC ACID)
Formula: C8-H6-Cl2-O3
Synonyms/Common Names
- 2,4-D
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage)
(S0704)
Completed
- Citation: Griffin RJ, Godfrey VB, Kim YC, Burka LT. Sex-dependent differences in the disposition of 2,4-dichlorophenoxyacetic acid in Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters. Drug Metab Dispos. 1997 Sep;25(9):1065-71.Pubmed Abstract
- Male and Female Rats: Sprague Dawley; Male and Female Mice: B6C3F1; Male and Female Hamsters: Syrian Golden
- Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous; Gavage; Intravenous)
(S0546)
Completed
- Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
- Dose: PRELM MICE IV: 5.2 MG/KG PO: 5.2, 156.3 MG/KG FEED: 31, 1875 PPM; PRELM RAT IV: 3.56 MG/KG PO: 3.56, 53.6 MG/KG FEED: 83, 2500 PPM; PRELM HAMSTER IV: 8 MG/KG PO: 8, 80 MG/KG FEED: 100, 1000 PPM. SA MICE IV: 1 MG/KG, PO: 1, 2, 5.2 MG/KG; SA RAT IV: 2 MG/KG PO: 1.5, 3.56, 7 MG/KG; SA HAMSTER IV: 8 MG/KG PO: 2, 8, 40 MG/KG..
- Toxicokinetic Study (Dosed-Feed)
(S0581)
Completed
- Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
- Dose: 14D: HAMSTER 12, 100, 500, 1000 OR 5000 PPM; 90D: RAT 17, 83, 250, 750, 1250 OR 2500 PPM; MICE 12, 28, 83, 250, 700 OR 1680 PPM; HAMSTERS 12, 100, 500, 1000, 5000 ppm.
Genetic Toxicology
- Drosophila
(846375)
Completed
- Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(079515)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Salmonella
(541375)
Completed
- Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
- Negative
- Salmonella
(843375)
Completed
- Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
- Negative
Organ Systems Toxicity
- Neurotoxicology Assessment (Gavage)
(NTA94009)
Completed
- Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
- Male Rats: F344/N