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Testing Status of 2,4-Dichlorophenoxyacetic acid 10451-Y

 

CASRN: 94-75-7

Formula: C8-H6-Cl2-O3

Synonyms/Common Names

  • 2,4-D

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0704)  Completed 
    • Citation: Griffin RJ, Godfrey VB, Kim YC, Burka LT. Sex-dependent differences in the disposition of 2,4-dichlorophenoxyacetic acid in Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters. Drug Metab Dispos. 1997 Sep;25(9):1065-71.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley; Male and Female Mice: B6C3F1; Male and Female Hamsters: Syrian Golden
    • Dose: 200 mg/kg. 5, 200 mg/kg. 5, 200 mg/kg [R,M].
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous; Gavage; Intravenous)  (S0546)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 3.56 mg/kg, preliminary; 2 mg/kg, single administration. 3.56, 53.6 mg/kg, feed: 83, 2500 ppm, preliminary; 1.5, 3.56, 7 mg/kg, single administration. 5.2 mg/kg, preliminary; 1 mg/kg, single administration. 5.2, 156.3 mg/kg, feed: 31, 1875 ppm, preliminary; 1, 2, 5.2 mg/kg, single administration. 8 mg/kg, preliminary; 8 mg/kg, single administration. 8, 80 mg/kg, feed: 100, 1000 ppm, preliminary. 2, 8, 40 mg/kg, single administration.
  • Toxicokinetic Study (Dosed-Feed)  (S0581)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 12, 100, 500, 1000 or 5000 ppm, 14d. 12, 100, 500, 1000, 5000 ppm, 90d. 12, 28, 83, 250, 700 or 1680 ppm, 90d. 17, 83, 250, 750, 1250 or 2500 ppm, 90d.

Genetic Toxicology

  • Drosophila  (846375)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (079515)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (541375)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 
  • Salmonella  (843375)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94009)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male Rats: F344/N