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Testing Status of 1,2-Dichlorobenzene (o-dichlorobenzene) 10456-T

 

CASRN: 95-50-1

Formula: C6-H4-Cl2

Synonyms/Common Names

  • Benzene, 1,2-Dichloro- (9Ci)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54944A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54944A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 30, 500 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54944A)  Completed 
    • TR-255 (NIH Number: 86-2511)  (Peer Review Approval 09/22/1982A )
      Toxicology and Carcinogenesis Studies of 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 60, 120 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Intraperitoneal Injection; Dosed-Water)  (S0062)  Completed 
    • Male Rats: Fischer 344
    • Dose: 0.033, 0.33, 3.0 mg/kg. 0.9, 1.8, 2.7, 3.6, 4.5 mmoles/kg.

Genetic Toxicology

  • Chromosome Aberrations  (388032)  Completed 
    • Mice
    •  Positive 
  • Chromosome Aberrations  (732739)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (934439)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (059536)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (279592)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (749046)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A44739)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Mouse Lymphoma  (881718)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (917014)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Sister Chromatid Exchanges  (388032)  Completed 
    • Mice
    • Sister Chromatid  Negative 
  • Sister Chromatid Exchanges  (732739)  Completed 
    • Mice
    • Sister Chromatid  Negative