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Testing Status of o-Toluidine 10457-X

 

CASRN: 95-53-4

Formula: C7-H9-N

Synonyms/Common Names

  • 2-Methylaniline (2-MA)
  • 2-Methylbenzenamine (9CI)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; in-vitro)  (S0608)  Completed 
    • Male Rats: F344/N; Male Human (Cell Lines)
    • Dose: rat: 35.7-46.8 uCi[14C]OTL, total volume 5 ml/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (489590)  Completed 
    • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A10316)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Micronucleus  (A12130)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (923898)  Completed 
    • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
    • Mice
    •  Positive 
  • Salmonella  (316866)  Completed 
    • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
    •  Positive