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Testing Status of 3-Chloro-p-toluidine 10460-D

 

CASRN: 95-74-9

Formula: C7-H8-Cl-N

Synonyms/Common Names

  • 3-Chloro-4-methylbenzenamine

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02040)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02040)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 315, 6800, M: 0, 810, 3750 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02040)  Completed 
    • TR-145 (NIH Number: 78-1701)  (Peer Review Approval 06/29/1978A )
      Bioassay of 3-Chloro-p-Toluidine for Possible Carcinogenicity (CASRN 95-74-9)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 1635, 3269 (AVG), FM: 0, 300, 600, MM: 0, 600, 1200 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (966841)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Equivocal 
  • Mouse Lymphoma  (836474)  Completed 
    • Mice
    •  Equivocal 
  • Salmonella  (374293)  Completed 
    •  Weakly Positive 
  • Salmonella  (991791)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative