Testing Status of 4,4'-Oxydianiline 10490-C
CASRN: 101-80-4
Formula: C12-H12-N2-O
Synonyms/Common Names
- 4,4'-Oxybisbenzenamine (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C50146)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C50146)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 300, 2000 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C50146)
Completed
- TR-205 (NIH Number: 80-1761)
(Peer Review Approval 02/15/1980A )
Bioassay of 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN 101-80-4) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: R: 0, 200, 400, 500, M: 0, 150, 300, 800 PPM/50 PER GROUP.
- TR-205 (NIH Number: 80-1761)
(Peer Review Approval 02/15/1980A )
Genetic Toxicology
- Chromosome Aberrations
(227174)
Completed
- Mice
- Positive
- Chromosome Aberrations
(774801)
Completed
- Mice
- Positive
- Drosophila
(943143)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(235006)
Completed
- Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(427822)
Completed
- Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
- Mice: B6C3F1
- Male Positive
- Mouse Lymphoma
(888699)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(113328)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Positive
- Sister Chromatid Exchanges
(227174)
Completed
- Mice
- Sister Chromatid Negative
- Sister Chromatid Exchanges
(774801)
Completed
- Mice
- Sister Chromatid Negative (Nonstandard Protocol)