Testing Status of N,N'-Diethylthiourea 10503-X
CASRN: 105-55-5
Formula: C5-H12-N2-S
Synonyms/Common Names
- 1,3-Diethyl-2-thiourea
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03816)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C03816)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 147, 464, M: 0, 680, 3150 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03816)
Completed
- TR-149 (NIH Number: 79-1705)
(Peer Review Approval 08/31/1978A )
Bioassay of N,N'-Diethylthiourea for Possible Carcinogenicity (CASRN 105-55-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0, 125, 250, M: 0, 250, 500 PPM/50 PER GROUP.
- TR-149 (NIH Number: 79-1705)
(Peer Review Approval 08/31/1978A )
Genetic Toxicology
- Drosophila
(215943)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(481340)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Mouse Lymphoma
(142424)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(013090)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative