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Testing Status of Geranyl acetate 10507-N

 

CASRN: 105-87-3

Formula: C12-H20-O2

Synonyms/Common Names

  • Acetic acid geraniol ester (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C54728)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54728)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 250, 4000, M: 0, 125, 2000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C54728)  Completed 
    • TR-252 (NIH Number: 88-2508)  (Peer Review Approval 09/22/1982A )
      Carcinogenesis Studies of Food Grade Geranyl Acetate (71% Geranyl Acetate, 29% Citronellyl Acetate) (CASRN 105-87-3) in F344/N Rats and B6C3F1 Mice (Gavage Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 1000, 2000, M: 0, 500, 1000 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (125080)  Completed 
    • Mice
    •  Positive 
  • Chromosome Aberrations  (A07926)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • Drosophila  (686825)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (076096)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (045954)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A07926)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (340860)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (139724)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
  • Sister Chromatid Exchanges  (125080)  Completed 
    • Mice
    • Sister Chromatid  Negative