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Testing Status of Acrolein 10515-N

 

CASRN: 107-02-8

Formula: C3-H4-O

Synonyms/Common Names

  • Acraldehyde
  • 2-Propenal

Short-Term Toxicity

  • 13 weeks (Gavage)  (C02802C)  Completed 
    • TOX-48 (NIH Number: 06-4413)
      Comparative Toxicity Studies of Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN 107-18-6) and Acrolein (CASRN 107-02-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.75, 1.25, 2.5, 5, OR 10 MG/KG M: 0, 1.25, 2.5, 5, 10, OR 20 MG/KG; 10 PER GROUP.

Genetic Toxicology

  • Drosophila  (395759)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (472710)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (134448)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A59477)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (326814)  Completed 
    •  Negative 
  • Salmonella  (326815)  Completed 
    •  Negative 
  • Salmonella  (870479)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive