Testing Status of bis(2-Chloro-1-methylethyl) ether 10523-N
CASRN: 108-60-1
Formula: C6-H12-Cl2-O
Synonyms/Common Names
- Bis(2-chloroisopropyl) ether
- Propane, 2,2'-oxybis(1-chloro-
Short-Term Toxicity
- 14-Day (Gavage)
(C50044A)
Completed
- Rats: F344/N
- 13-Week (Gavage)
(C50044A)
Completed
- Rats: F344/N
- Dose: 0, 10, 250 MG/KG/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Gavage)
(C50044A)
Completed
- TR-191 (NIH Number: 79-1747)
(Peer Review Approval 05/01/1979A )
Bioassay of Technical Grade Bis(2-chloro-1-methylethyl) ether for Possible Carcinogenicity (CASRN 108-60-1) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Dose: 0, 100, 200 MG/KG/50 PER GROUP.
- TR-191 (NIH Number: 79-1747)
(Peer Review Approval 05/01/1979A )
- 2-Year (Gavage)
(C50044B)
Completed
- TR-239 (NIH Number: 83-1795)
(Peer Review Approval 12/16/1981A )
Carcinogenesis Bioassay of Bis(2-chloro-1-methylethyl)ether (~70) (CASRN 108-60-1) Containing 2-Chloro-1-methylethyl(2-chloropropyl)ether (~30) (CASRN 83270-31-9) in B6C3F1 Mice (Gavage Study) - Mice: B6C3F1
- Carcinogenesis Results
- Male Mice Positive
- Female Mice Positive
- Dose: 0, 100, 200 MG/KG/50 PER GROUP.
- TR-239 (NIH Number: 83-1795)
(Peer Review Approval 12/16/1981A )
Genetic Toxicology
- Chromosome Aberrations
(500655)
Completed
- Mice
- Negative
- Drosophila
(945998)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal
- In Vitro Cytogenetics (CA/SCE)
(453382)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(151175)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(035504)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Weakly Positive
- Salmonella
(082677)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Positive
- Salmonella
(175248)
Completed
- Positive
- Salmonella
(247021)
Completed
- Positive
- Salmonella
(856126)
Completed
- Positive
- Salmonella
(891894)
Completed
- Positive
- Sister Chromatid Exchanges
(500655)
Completed
- Mice
- Sister Chromatid Negative