Testing Status of 2,4-Dinitrotoluene 10558-G
CASRN: 121-14-2
Formula: C7-H6-N2-O4
Synonyms/Common Names
- 1-Methyl-2,4-dinitrobenzene
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01865)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C01865)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, .00375, .015 %/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01865)
Completed
- TR-054 (NIH Number: 78-1360)
(Peer Review Approval 01/18/1978A )
Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity (CASRN 121-14-2) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0, .008, .02 (AVG), M: 0, .008, .04 (AVG) %/50 PER GROUP.
- TR-054 (NIH Number: 78-1360)
(Peer Review Approval 01/18/1978A )
Genetic Toxicology
- Drosophila
(050763)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Negative
- Drosophila
(957177)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal
- In Vitro Cytogenetics (CA/SCE)
(322897)
Completed
- Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Mouse Lymphoma
(693724)
Completed
- Mice
- Positive
- Salmonella
(683014)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
- Salmonella
(N-9340)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
Organ Systems Toxicity
- 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)
(T0090)
Completed
- Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
- Female Mice: Swiss
- Dose: 390 MG/KG BODY WT..