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Testing Status of Chlorodibromomethane 10570-R

 

CASRN: 124-48-1

Formula: C-H-Br2-Cl

Synonyms/Common Names

  • Dibromochloromethane

Short-Term Toxicity

  • 14-Day (Gavage)  (C55254)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55254)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 15, 25 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C55254)  Completed 
    • TR-282 (NIH Number: 85-2538)  (Peer Review Approval 03/23/1984A )
      Toxicology and Carcinogenesis Studies of Chlorodibromomethane (CASRN 124-48-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 40, 80, M: 0, 50, 100 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (687058)  Completed 
    • Mice
    •  Positive 
  • In Vitro Cytogenetics (CA/SCE)  (096876)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (261721)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (558894)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (988921)  Completed 
    • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
    • Mice
    •  Positive 
  • Micronucleus  (306321)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (065376)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A32951)  Completed 
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (687058)  Completed 
    • Mice
    • Sister Chromatid  Negative 

Organ Systems Toxicity

  • 28 days Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94003)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 50, 150, OR 450 PPM.