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Testing Status of tris(2,3-Dibromopropyl) phosphate 10571-V

 

CASRN: 126-72-7

Formula: C9-H15-Br6-O4-P

Synonyms/Common Names

  • 2,3-Dibromo-1-propanol phosphate (3:1) (9CI)
  • Tris(dibromopropyl)phosphate

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03270)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03270)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 1, 100, M: 0, 10, 1000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03270)  Completed 
    • TR-076 (NIH Number: 78-1326)  (Peer Review Approval 03/06/1978A )
      Bioassay of Tris (2,3-Dibromopropyl) Phosphate for Possible Carcinogenicity (CASRN 126-72-7)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 50, 100, M: 0, 500, 1000 PPM/55 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0006)  Completed 
    • Citation: Nomeir AA, Matthews HB. Metabolism and disposition of the flame retardant tris(2,3-dibromopropyl) phosphate in the rat. Toxicol Appl Pharmacol. 1983; 67:357-369.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: PO/IV: 1.39 MG/KG.
  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0036)  Completed 
    • Citation: Lynn RK, Garvie-Gould C, Wong K, Kennish JM. Metabolism, distribution, and excretion of the flame retardant, tris(2,3-dibromopropyl) phosphate (tris-bp) in the rat: identification of mutagenic and nephrotoxic metabolites. Toxicol Appl Pharmacol. 1982 Mar 30;63(1):105-19. Pubmed Abstract
    • Male Rats: F344/N
  • Cell Proliferation (Dosed-Feed)  (S0147)  Completed 
    • Citation: Cunningham ML, Elwell MR, Matthews HB. Site-specific cell proliferation in renal tubular cells by the renal tubular carcinogen tris(2,3-dibromopropyl)phosphate. Environ Health Perspect. 1993 Dec;101 Suppl 5:253-7.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 50, 100 PPM.
  • Cell Proliferation  (S0672)  Completed 
    • Citation: Cunningham ML, Elwell MR, Matthews HB. Relationship of carcinogenicity and cellular proliferation induced by mutagenic noncarcinogens vs carcinogens. III. Organophosphate pesticides vs tris(2,3-dibromopropyl)phosphate. Fundam Appl Toxicol. 1994 Oct;23(3):363-9.Pubmed Abstract
    • Male Rats: F344/N
  • Mechanisms (Intravenous)  (S0442)  Completed 
    • Citation: Morales NM, Matthews HB. In vivo binding of the flame retardants tris(2,3-dibromopropyl) phosphate and tris(1,3-dichloro-2-propyl) phosphate to macromolecules of mouse liver, kidney and muscle. Bull Environ Contam Toxicol. 1980 Jul;25(1):34-8.Pubmed Abstract
    • Male Mice

Genetic Toxicology

  • Salmonella  (N-9383)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248