Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Chloroprene 10573-D

 

CASRN: 126-99-8

Formula: C4-H5-Cl

Synonyms/Common Names

  • 2-Chlor-1,3-butadiene

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C50522)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Inhalation)  (C50522)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0, 32, 80, 200, 500PPM M:0, 12, 32, 80, 200PPM.
  • 26 weeks (Inhalation)  (C50522C)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Dose: FM: 0, 2.0, 12.8, or 80 ppm; 20/dose.
  • 26 weeks (Inhalation)  (C50522D)  Completed 
    • Mice: FVB/N; Mice: Tg.AC (FVB/N) Hemizygous; Mice: Tg.Lac1/C57BL/6 (Big Blue)
    • Dose: FM: 0, 2.0, 12.8, or 80 ppm; 20/strain/dose.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C50522B)  Completed 
    • TR-467 (NIH Number: 98-3957)  (Peer Review Approval 12/11/1996A )
      Toxicology and Carcinogenesis Studies of Chloroprene in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 12.8, 32.0, or 80.0 ppm; 50/sex/species/group.

Genetic Toxicology

  • Chromosome Aberrations  (A84892)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (433265)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A18069)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Female Negative 
  • Micronucleus  (A73731)  Completed 
    • Mice: MICE
    • Female Negative 
  • Micronucleus  (A74378)  Completed 
    • Mice: B6C3F1
    • Male Negative (Nonstandard Protocol) 
  • Micronucleus  (A75483)  Completed 
    • Mice: MICE
    • Female Negative 
  • Micronucleus  (A84892)  Completed 
    • Micronucleus  (A84893)  Completed 
      • Citation: Tice, R.R., Boucher, R., Luke, C.A., Paquette, D.F., Melnick, R.L., and Shelby, M.D. Chloroprene and isoprene: Cytogenetic studies in mice. Mutagenesis. Vol. 3 (1988) 141-146
      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
      • Mice: B6C3F1
      • Male Negative 
      • Female Negative 
    • Salmonella  (703184)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Negative 
    • Sister Chromatid Exchanges  (A74378)  Completed 
      • Mice
      • Sister Chromatid  Negative (Nonstandard Protocol) 
    • Sister Chromatid Exchanges  (A84892)  Completed 
      • Mice

    Organ Systems Toxicity

    • Conventional Teratology (Inhalation)  (TER91042)  Completed 
      • Female Rabbits: New Zealand White
      • Rabbits Maternal Negative 
      • Rabbits Fetal Negative 
      • Dose: 0, 10, 40, 175 PPM.
    • Neurotoxicology Assessment (Inhalation)  (NTA94018)  Completed 
      • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
      • Male Rats: F344/N