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Testing Status of Diallyl phthalate 10578-X

 

CASRN: 131-17-9

Formula: C14-H14-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, di-2-propenyl ester
  • Diallylphthalate

Short-Term Toxicity

  • 2 weeks (Gavage)  (C50657A)  Completed 
    • Mice: B6C3F1
  • 14-Day (Gavage)  (C50657B)  Completed 
    • Rats: F344/N
  • 13 weeks (Gavage)  (C50657A)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 25, 400 MG/KG/10 PER GROUP.
  • 13-Week (Gavage)  (C50657B)  Completed 
    • Rats: F344/N
    • Dose: 0, 25, 400 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C50657A)  Completed 
    • TR-242 (NIH Number: 83-1798)  (Peer Review Approval 06/16/1982A )
      Carcinogenesis Bioassay of Diallyl Phthalate (CASRN 131-17-9) in B6C3F1 Mice (Gavage Study)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Equivocal 
      • Female Mice Equivocal 
    • Dose: 0, 150, 300 MG/KG/50 PER GROUP.
  • 2-Year (Gavage)  (C50657B)  Completed 
    • TR-284 (NIH Number: 85-2540)  (Peer Review Approval 03/23/1984A )
      Toxicology and Carcinogenesis Studies of Diallylphthalate (CASRN 131-17-9) in F344/N Rats (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
    • Dose: 0, 50, 100 MG/KG/50 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage; Intravenous)  (S0228)  Completed 
    • Citation: Eigenberg DA, Carter DE, Schram KH, Sipes IG. Examination of the differential hepatotoxicity of diallyl phthalate in rats and mice. Toxicol Appl Pharmacol. 1986 Oct;86(1):12-21.Pubmed Abstract
    • Rats; Mice
    • Dose: ORAL: 1, 10, 100 IV: 10 MG/KG.

Genetic Toxicology

  • Chromosome Aberrations  (993263)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    •  Positive 
  • Drosophila  (574773)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (154517)  Completed 
    • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (730162)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A49968)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (871217)  Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    • Mice
    •  Positive 
  • Salmonella  (079950)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (258261)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Sister Chromatid Exchanges  (993263)  Completed 
    • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
    • Mice
    • Sister Chromatid  Positive