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Testing Status of 3-Amino-9-ethylcarbazole HCl 10579-C

 

CASRN: 6109-97-3

Formula: C14-H14-N2.Cl-H

Synonyms/Common Names

  • 9H-Carbazol-3-amine, 9-ethyl-, monohydrochloride (1:1)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C03043)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C03043)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 40, 1440 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C03043)  Completed 
    • TR-093 (NIH Number: 78-1337)  (Peer Review Approval 06/29/1978A )
      Bioassay of 3-Amino-9-ethylcarbazole Hydrochloride for Possible Carcinogenicity (CASRN 132-32-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 800, 2000, M: 0, 800, 1200 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (688225)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (918212)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive