Testing Status of p-Nitrosodiphenylamine 10605-K
CASRN: 156-10-5
Formula: C12-H10-N2-O
Synonyms/Common Names
- 4-Nitroso-N-phenylbenzenamine (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C02244)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C02244)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 6800, 31530, M: 0, 1180, 25520 PPM/5 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C02244)
Completed
- TR-190 (NIH Number: 79-1746)
(Peer Review Approval 10/25/1978A )
Bioassay of p-Nitrosodiphenylamine for Possible Carcinogenicity (CASRN 156-10-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Negative
- Male Mice Positive
- Female Mice Negative
- Dose: R: 0, 2500, 5000, M: 0, 4254, 9000 (AVG) PPM/50 PER GROUP.
- TR-190 (NIH Number: 79-1746)
(Peer Review Approval 10/25/1978A )
Genetic Toxicology
- Drosophila
(707024)
Completed
- Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(976337)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Mouse Lymphoma
(722133)
Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mice
- Mouse Lymphoma
(986345)
Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mice
- Salmonella
(315639)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Weakly Positive