Testing Status of Chloral hydrate 10609-C
CASRN: 302-17-0
Related: CHLORAL 75-87-6
Formula: C2-H3-Cl3-O2
Synonyms/Common Names
- Chloraldurat
- Lorinal
- Noctec
- Trichloroacetaldehyde monohydrate
- 2,2,2-Trichloro-1,1-ethanediol
Short-Term Toxicity
- 2 weeks (Gavage)
(C92010)
Completed
- Rats: F344/N; Mice: MV
- Dose: R&M: 0, 50, 100, 200, 400, OR 800 MG/KG; 8/GROUP/SEX/SPECIES.
- 2 weeks (Gavage)
(C92010B)
Completed
- Citation: Beland, F.A., Schmitt, T.C., Fullerton, N.F., and Young, J.F. (1998). Metabolism of chloral hydrate in mice and rats after single and multiple doses. J. Toxicol. Environ. Health, Part A 54, 209-226.
- TOX-59 (NIH Number: 99-3944)
Toxicity and Metabolism Studies of Chloral Hydrate (CASRN 302-17-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: MV
Long-Term Carcinogenicity
- 2 years (Gavage)
(C92010)
Completed
- TR-502 (NIH Number: 02-4436)
(Peer Review Approval 05/18/2000A )
Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies) - Mice: MV
- Carcinogenesis Results
- Female Mice Equivocal Evidence
- Dose: 0, 25, 50, OR 100 MG/KG.
- TR-502 (NIH Number: 02-4436)
(Peer Review Approval 05/18/2000A )
- 2 years (Gavage)
(C92010C)
Completed
- TR-503 (NIH Number: 03-4437)
(Peer Review Approval 05/18/2000A )
Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary Controlled) (CASRN 302-17-0) in Male B6C3F1 Mice (Gavage Study) - Mice: MV
- Carcinogenesis Results
- Male Mice Some Evidence
- Dose: 0, 25, 50, OR 100 MG/KG.
- TR-503 (NIH Number: 03-4437)
(Peer Review Approval 05/18/2000A )
Genetic Toxicology
- Drosophila
(852155)
Completed
- Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
- Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal
- In Vitro Cytogenetics (CA/SCE)
(043571)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(518954)
Completed
- Mice: B6C3F1
- Male Positive
- Salmonella
(780474)
Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Positive
Organ Systems Toxicity
- single Total Reproductive Capacity (Intraperitoneal Injection)
(TRC98034)
Completed
- Female Mice: SEC/E X C57B1/E
- Dose: 400 MG/KG.