Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Chloral hydrate 10609-C

 

CASRN: 302-17-0

Formula: C2-H3-Cl3-O2

Synonyms/Common Names

  • Chloraldurat
  • Lorinal
  • Noctec
  • Trichloroacetaldehyde monohydrate
  • 2,2,2-Trichloro-1,1-ethanediol

Short-Term Toxicity

  • 2 weeks (Gavage)  (C92010)  Completed 
    • Rats: F344/N; Mice: MV
    • Dose: R&M: 0, 50, 100, 200, 400, OR 800 MG/KG; 8/GROUP/SEX/SPECIES.
  • 2 weeks (Gavage)  (C92010B)  Completed 
    • Citation: Beland, F.A., Schmitt, T.C., Fullerton, N.F., and Young, J.F. (1998). Metabolism of chloral hydrate in mice and rats after single and multiple doses. J. Toxicol. Environ. Health, Part A 54, 209-226.
    • TOX-59 (NIH Number: 99-3944)
      Toxicity and Metabolism Studies of Chloral Hydrate Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: MV

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C92010)  Completed 
    • TR-502 (NIH Number: 02-4436)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies)
    • Mice: MV
    • Carcinogenesis Results
      • Female Mice Equivocal Evidence 
    • Dose: 0, 25, 50, OR 100 MG/KG.
  • 2 years (Gavage)  (C92010C)  Completed 
    • TR-503 (NIH Number: 03-4437)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary Controlled) (CASRN 302-17-0) in Male B6C3F1 Mice (Gavage Study)
    • Mice: MV
    • Carcinogenesis Results
      • Male Mice Some Evidence 
    • Dose: 0, 25, 50, OR 100 MG/KG.

Genetic Toxicology

  • Drosophila  (852155)  Completed 
    • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (043571)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (518954)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (780474)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 

Organ Systems Toxicity

  • single Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98034)  Completed 
    • Female Mice: SEC/E X C57B1/E
    • Dose: 400 MG/KG.