Testing Status of Diazinon 10611-D
CASRN: 333-41-5
Formula: C12-H21-N2-O3-P-S
Synonyms/Common Names
- Phosphorothioic acid, O,O-diethyl O-(6-methyl-2-(1-methylethyl)-4-pyrimidinyl) ester
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C08673)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Dosed-Feed)
(C08673)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 0, 50, 3200 PPM/10 PER GROUP.
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C08673)
Completed
- TR-137 (NIH Number: 79-1392)
(Peer Review Approval 12/13/1978A )
Bioassay of Diazinon for Possible Carcinogenicity (CASRN 333-41-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0, 400, 800, M: 0, 100, 200 PPM/50 PER GROUP.
- TR-137 (NIH Number: 79-1392)
(Peer Review Approval 12/13/1978A )
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(140422)
Completed
- Sister Chromatid Exchange Negative
- Chromosome Aberrations Negative
- Mouse Lymphoma
(180250)
Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Mice
- Positive
- Salmonella
(217556)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Negative
- Salmonella
(N-9278)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248