Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Sodium thioglycolate 10613-K

 

CASRN: 367-51-1

Formula: C2-H4-O2-S.Na

Synonyms/Common Names

  • Mercaptoacetic acid, monosodium salt (9CI)
  • Thioglycolic acid, sodium salt

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C98007)  Completed 
    • TOX-80 (NIH Number: 16-5936)
      Toxicity Studies of Sodium Thioglycolate (CASRN 367-51-1) Administered Dermally to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 11.25, 22.5, 45, 90, or 180 mg/kg; M: 0, 22.5, 45, 90, 180, or 360 mg/kg.
  • 13 weeks (Topical Application)  (C98007)  Completed 
    • TOX-80 (NIH Number: 16-5936)  (Tox Peer Review 12/00/2013A )
      Toxicity Studies of Sodium Thioglycolate (CASRN 367-51-1) Administered Dermally to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 11.25, 22.5, 45, 90, or 180 mg/kg; M: 0, 22.5, 45, 90, 180, or 360 mg/kg.

Genetic Toxicology

  • Micronucleus  (A85427)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Salmonella  (471613)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 6 to 19 GD Conventional Teratology (Topical Application)  (TER98009)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 100, OR 200 MG/KG/DAY.
  • 6 to 29 GD Conventional Teratology (Topical Application)  (TER99005)  Completed 
    • Female Rabbits: New Zealand White
    • Dose: 0, 10, 15, 25 OR 65 MG/KG/DAY.
  • 14 days (nonpregnant pilot); pregnant screen GD 1-19 and GD 6-19 Teratology Pilot Studies (Topical Application)  (TRP98009)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 6, 60 OR 600 MG/KG/DAY (NONPREGNANT PILOT 14 DAYS); 0, 525 MG/KG/DAY (PREGNANT SCREEN 1-19); 0, 50, 250, 350, OR 525 MG/KG/DAY (PREGNANT SCREEN 6-19).
  • 6 to 29 GD Teratology Pilot Studies (Topical Application)  (TRP99008)  Completed 
    • Female Rabbits: New Zealand White
    • Dose: 0, 25, 50, 100, 150, OR 175 MG/KG/DAY.