Testing Status of Glycidol 10630-P

CASRN: 556-52-5

Formula: C3-H6-O2

Synonyms/Common Names

• 2,3-Epoxy-1-propanol
• Oxiranemethanol (9CI)

Short-Term Toxicity

• 14-Day (Gavage)  (C55549)  Completed 
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C55549)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 25, 400, M: 0, 19, 300 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

• 2 years (Gavage)  (C55549)  Completed 
  • TR-374 (NIH Number: 90-2829)  (Peer Review Approval 06/27/1989A )
    Toxicology and Carcinogenesis Studies of Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Clear Evidence 
    • Female Rats Clear Evidence 
    • Male Mice Clear Evidence 
    • Female Mice Clear Evidence 
  • Dose: R: 0, 38, 75, M: 0, 25, 50 MG/KG/50 PER GROUP.

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage; Intravenous)  (S0161)  Completed 
  • Citation: Nomeir AA, Silveira DM, Ferrala NF, Markham PM, McComish MF, Ghanayem BI, Chadwick M. Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration. J Toxicol Environ Health. 1995 Feb;44(2):203-17.Pubmed Abstract
  • Male Rats: F344/N
  • Dose: 37.5, 75 mg/kg.

Genetic Toxicology

• Drosophila  (381221)  Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Positive 
• In Vitro Cytogenetics (CA/SCE)  (536149)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (196476)  Completed 
  • Mice: B6C3F1
  • Male Positive 
• Micronucleus  (A37837)  Completed 
  • Mice: P16(Ink4a)/(+/-) (C57BL/6)
  • Male Positive 
  • Female Positive 
• Micronucleus  (A48958)  Completed 
  • Mice: P16(Ink4a)/(+/-) (C57BL/6)
  • Male Negative 
  • Female Negative 
• Micronucleus  (A58625)  Completed 
  • Mice: P16(Ink4a)/(+/-) (C57BL/6)
  • Male Negative 
  • Female Negative 
• Micronucleus  (A75768)  Completed 
  • Mice: P16(Ink4a)/(+/-) (C57BL/6)
  • Male Negative 
  • Female Negative 
• Micronucleus  (A92101)  Completed 
  • Mice: P16(Ink4a)/(+/-) (C57BL/6)
  • Male Positive 
  • Female Positive 
• Mouse Lymphoma  (036941)  Completed 
  • Mice
  •  Positive 
• Salmonella  (278371)  Completed 
  • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
  •  Positive 
• Salmonella  (971355)  Completed 
  • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
  •  Positive 

Organ Systems Toxicity

• 14 days Immunotoxicity (Gavage)  (IMM20002)  Completed 
  • Female Mice: B6C3F1
  • Dose: STUDY 1: 0, 25, 50, 75, 100, 125, 150, 200, 250, OR 300 MG/KG; STUDY 2: 0, 50, 125, 200, 300, OR 400 MG/KG.
• 14 days Immunotoxicity (Gavage)  (IMM91019)  Completed 
  • Female Mice: B6C3F1
  • Dose: 0, 25, 125, 250 MG/KG.
• Preimplantation Zygote Effects (Gavage)  (PZEF49)  Completed 
  • Citation: Rutledge, J.C., Generoso, W.M., Shourbaji, A., Cain, K.T., Gans, M., and Oliva, J. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutation Research 296: 167-177 (1992).
  • Female Mice: C3H X C57BL
  • Mice Female Positive 
• Total Reproductive Capacity (Dosed-Water)  (TRC98035)  Completed 
  • Female Mice
  • Mice Female Negative