Testing Status of o-Toluidine hydrochloride 10654-W
CASRN: 636-21-5
Related: O-TOLUIDINE 95-53-4
Formula: C7-H9-N.Cl-H
Synonyms/Common Names
- 2-Methylbenzenamine hydrochloride (9CI)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C02335)
Completed
- Rats: F344/N; Mice: B6C3F1
- 1 week (Dosed-Feed)
(C02335B)
Completed
- TOX-44 (NIH Number: 96-3936)
Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride (CASRN 636-21-5) Administered in Feed to Male F344/N Rats - Rats: F344/N
- TOX-44 (NIH Number: 96-3936)
- 13-Week (Dosed-Feed)
(C02335)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 1000, 50000, M: 0, 3100, 50000 PPM/5 PER GROUP.
- 26 weeks (Dosed-Feed)
(C02335B)
Completed
- TOX-44 (NIH Number: 96-3936)
(Tox Peer Review 08/00/1995A )
Comparative Toxicity and Carcinogenicity Studies ofo-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride (CASRN 636-21-5) Administered in Feed to Male F344/N Rats - Rats: F344/N
- Dose: O AND 0 ALTERED MICROFLORA; 20/GRP; 5000 PPM; 60/GRP.
- TOX-44 (NIH Number: 96-3936)
(Tox Peer Review 08/00/1995A )
Long-Term Carcinogenicity
- 148 weeks (Dosed-Feed)
(C02335)
Completed
- TR-153 (NIH Number: 79-1709)
(Peer Review Approval 10/25/1978A )
Bioassay of o-Toluidine Hydrochloride for Possible Carcinogenicity (CASRN 636-21-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Positive
- Female Mice Positive
- Dose: R: 0, 3000, 6000, M: 0, 1000, 3000 PPM/50 PER GROUP.
- TR-153 (NIH Number: 79-1709)
(Peer Review Approval 10/25/1978A )
Genetic Toxicology
- Chromosome Aberrations
(938330)
Completed
- Mice
- Not a Valid Test
- Drosophila
(537539)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Drosophila
(885510)
Completed
- Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- In Vitro Cytogenetics (CA/SCE)
(867721)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Equivocal
- Salmonella
(531447)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Positive
- Salmonella
(539939)
Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative
- Sister Chromatid Exchanges
(938330)
Completed
- Mice
- Sister Chromatid Positive