Testing Status of Dimethyl methylphosphonate 10660-N
CASRN: 756-79-6
Formula: C3-H9-O3-P
Synonyms/Common Names
- Methanephosphonic acid dimethyl ester
Short-Term Toxicity
- 14-Day (Gavage)
(C54762)
Completed
- Rats: F344/N; Mice: B6C3F1
- 13-Week (Gavage)
(C54762)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 250, 4000, M: 0, 250, 8000 MG/KG/10 PER GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C54762)
Completed
- TR-323 (NIH Number: 88-2579)
(Peer Review Approval 08/19/1986A )
Toxicology and Carcinogenesis Studies of Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice Inadequate Study
- Female Mice No Evidence
- Dose: R: 0, 500, 1000, M: 0, 1000, 2000 MG/KG/50 PER GROUP.
- TR-323 (NIH Number: 88-2579)
(Peer Review Approval 08/19/1986A )
Genetic Toxicology
- Drosophila
(212220)
Completed
- Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Negative
- In Vitro Cytogenetics (CA/SCE)
(202021)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- In Vitro Cytogenetics (CA/SCE)
(314062)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Mouse Lymphoma
(369588)
Completed
- Mice
- Positive
- Salmonella
(842521)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)
(T0117)
Completed
- Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
- Female Mice: Swiss
- Dose: 4175 MG/KG BODY WEIGHT.