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Testing Status of Decabromodiphenyl Ether 10672-E

 

CASRN: 1163-19-5

Formula: C12-Br10-O

Synonyms/Common Names

  • BDE-209
  • Deca BDE
  • 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE-209)
  • Decabromodiphenyl Oxide
  • Flame Retardant 2
  • 1,1'-Oxybis(2,3,4,5,6-pentabromobenzene)

Short-Term Toxicity

  • 5 days (Gavage)  (C10672)  Completed 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
  • 14-Day (Dosed-Feed)  (C55287)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55287)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 3100, 50000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C55287)  Completed 
    • TR-309 (NIH Number: 86-2565)  (Peer Review Approval 08/14/1985A )
      Toxicology and Carcinogenesis Studies of Decabromodiphenyl Oxide (CASRN 1163-19-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 25000, 50000 PPM/50 PER GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Dosed-Feed; Intravenous)  (S0210)  Completed 
    • Citation: el Dareer SM, Kalin JR, Tillery KF, Hill DL. Disposition of decabromobiphenyl ether in rats dosed intravenously or by feeding. J Toxicol Environ Health. 1987;22(4):405-15.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.0250, 0.0509, 0.250, 0.487, 2.49, 4.99%; or 0.0277, 4.80%. 1 mg/kg.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G10672)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G10672B)  On Test 
    • Human (Cell Lines)
  • In Vitro Cytogenetics (CA/SCE)  (856353)  Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A36713)  Completed 
    • Rats: Fischer 344
    • Male Positive 
  • Mouse Lymphoma  (490548)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (185983)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T10672)  Completed 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.