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Testing Status of Ethylene Glycol Monomethyl Ether (EGMME) 10681-H

 

CASRN: 109-86-4

Formula: C3-H8-O2

Synonyms/Common Names

  • EGMME
  • 2-Methoxyethanol

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C62135)  Completed 
    • TOX-26 (NIH Number: 93-3349)  (Peer Review Approval 12/02/1992A )
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
  • 8 weeks (Dosed-Water)  (C62135C)  Completed 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N
    • Dose: R: 0, 3000, 6000 PPM /20 PER GROUP.
  • 13 weeks (Dosed-Water)  (C62135)  Completed 
    • TOX-26 (NIH Number: 93-3349)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CASRNs 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: CORE STUDY: R: 0, 750, 1500, 3000, 4500, 6000, M: 0, 2000, 4000, 6000, 8000, 10000 PPM/ 10 PER GROUP; STOP STUDY DOSES: R: 0, 1500, 3000, 6000 PPM/ 30 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation; Topical Application)  (S0096)  Completed 
    • Citation: Sabourin PJ, Medinsky MA, Thurmond F, Birnbaum LS, Henderson RF. Effect of dose on the disposition of methoxyethanol, ethoxyethanol, and butoxyethanol administered dermally to male F344/N rats. Fundam Appl Toxicol. 1992 Jul;19(1):124-32.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 5 & 46 PPM.
  • Absorption Disposition Metabolism Elimination (Dosed-Water)  (S0513)  Completed 
    • Citation: Medinsky MA, Singh G, Bechtold WE, Bond JA, Sabourin PJ, Birnbaum LS, Henderson RF. Disposition of three glycol ethers administered in drinking water to male F344/N rats. Toxicol Appl Pharmacol. 1990 Mar 1;102(3):443-55.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0782)  Completed 
    • Citation: Ghanayem BI, Chapin RE. Calcium channel blockers protect against ethylene glycol monomethyl ether (2-methoxyethanol)-induced testicular toxicity. Exp Mol Pathol. 1990 Jun;52(3):279-90.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 200, 300 mg egme/kg (some in combination with 1, 2, 3, or 4 doses of verapamil and diltiazem).

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM91028)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 3, 10, OR 30%.
  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83098)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .5, 1.0, 2.0%; N/A; N/A.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84055)  Completed 
    • Male and Female Mice: Swiss
    • Dose: 0, 1, .25, .5, 1.0, 2.0%; 0, .1, .2, .4%; 0, .2%; 0, .1%.
  • 7 days continuous premating period Continuous Breeding (Legacy) (Dosed-Water)  (RACB86057)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, .03, .1, .3%; N/A; 0, .03, .1%.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB86099)  Completed 
    • Male and Female Mice: C3H
    • Dose: N/A; 0, .03, .1, .3%; N/A; 0, .03, .1%.
  • 7 days continuous premating period Continuous Breeding (Legacy) (Dosed-Water)  (RACB87058)  Completed 
    • Male and Female Mice: C57BL/6
    • Dose: N/A; 0, .03, .1, .3%; N/A; 0, .03, .1%.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB88100)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: N/A; 0, .006, .012, .024, .024%; 0, .024%; 0, .006, .012, .024%.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB89056)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: N/A; 0, .01, .03, .1%; 0, .01, .03, .1%; 0, .01, .03%.
  • 28 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT97002)  Completed 
    • Male and Female Mice: Swiss CD-1
    • Dose: 0, 70, 250, OR 700 MG/KG/DAY.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0065A)  Completed 
    • Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • Female Mice: Swiss
    • Dose: 1400 MG/KG BD WT.
  • 11 GD (plug = GD 0) Conventional Teratology (Gavage)  (T0065D)  Completed 
    • Female Mice: Swiss
    • Dose: 304 mg/kg (4.0 mmol/kg).