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Testing Status of o-Chlorobenzalmalononitrile (CS) 10711-H

 

CASRN: 2698-41-1

Formula: C10-H5-Cl-N2

Synonyms/Common Names

  • 2-Chlorobenzalmalononitrile
  • CS
  • Malononitrile, (o-chlorobenzylidene)-
  • Propanedinitrile, ((2-chlorophenyl)methylene)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55118)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C55118)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, .4, 6.0 MG/M3/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C55118)  Completed 
    • TR-377 (NIH Number: 90-2832)  (Peer Review Approval 11/20/1989A )
      Toxicology and Carcinogenesis Studies of CS2 (94% o-Chlorobenzalmalononitrile, CASRN 2698-41-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, .075, .25, .75, M: 0, .75, 1.5 MG/M3/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (171099)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (668414)  Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    • Mice
    •  Positive 
  • Salmonella  (704784)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Equivocal 
  • Salmonella  (825580)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Equivocal