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Testing Status of FD & C Yellow No. 6 10714-V

 

CASRN: 2783-94-0

Formula: C16-H12-N2-O7-S2.2Na

Synonyms/Common Names

  • 6-Hydroxy-5-((p-sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt (9CI)
  • Sunset Yellow FCF
  • Yellow No. 6, FD & C

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C53907)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C53907)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6000, 100000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C53907)  Completed 
    • TR-208 (NIH Number: 81-1764)  (Peer Review Approval 06/27/1980A )
      Carcinogenesis Bioassay of FD & C Yellow No. 6 (CASRN 2783-94-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: 0, 12500, 25000 PPM/50 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (848256)  Completed 
    • Mice
    •  Negative 
  • Drosophila  (948568)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (356840)  Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Micronucleus  (029483)  Completed 
    • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (030453)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Positive 
  • Salmonella  (098811)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Sister Chromatid Exchanges  (848256)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)