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4-Chloro-o-toluidine hydrochloride (3165-93-3)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020288


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Negative, Male, Rats
View
  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 4-Chloro-o-toluidine hydrochloride (3165-93-3).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 4-Chloro-o-toluidine hydrochloride (3165-93-3).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4-Chloro-o-toluidine hydrochloride (3165-93-3).
Bacterial Mutagenicity
View
  • Equivocal
View
  • Negative

Citation Information


NTP. 4-Chloro-o-toluidine hydrochloride (3165-93-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-165 Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CASRN 3165-93-3)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-toluidine Hydrochloride (3165-93-3) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-toluidine Hydrochloride (3165-93-3) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-toluidine Hydrochloride (3165-93-3) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-toluidine Hydrochloride (3165-93-3) in Female B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 4-Chloro-o-toluidine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 402517
Summary Data
Genetic Toxicity Evaluation of 4-Chloro-o-toluidine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 721054
Summary Data