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Testing Status of Iodinated glycerol 10733-G

 

CASRN: 5634-39-9

Formula: C6-H11-I-O3

Synonyms/Common Names

  • 2-(1-Iodoethyl)-1,3-dioxolane-4-methanol (9CI)

Short-Term Toxicity

  • 14-Day (Gavage)  (C55469)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C55469)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 0.31, 0.5 G/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 109 weeks (Gavage)  (C55469)  Completed 
    • TR-340 (NIH Number: 90-2596)  (Peer Review Approval 10/04/1988A )
      Toxicology and Carcinogenesis Studies of Iodinated Glycerol (Organidin®) (CASRN 5634-39-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: FR&FM: 0, 62, 125, MR&MM: 0, 125, 250 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Drosophila  (662601)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • In Vitro Cytogenetics (CA/SCE)  (773890)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Micronucleus  (985532)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Mouse Lymphoma  (616705)  Completed 
    • Mice
    •  Positive 
  • Salmonella  (139180)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive