Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of C.I. Acid Orange 3 10737-X

 

CASRN: 6373-74-6

Formula: C18-H14-N4-O7-S.Na

Synonyms/Common Names

  • 5-((2,4-Dinitrophenyl)amino)-2-(phenylamino)benzenesulfonic acid monosodium salt
  • Orange 3, C.I. Acid

Short-Term Toxicity

  • 14-Day (Gavage)  (C54911)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C54911)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 94, 1500, M: 0, 250, 2000 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C54911)  Completed 
    • TR-335 (NIH Number: 89-2591)  (Peer Review Approval 07/14/1987A )
      Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 375, 750 MG/KG MM: 0, 125, 250 MG/KG FM: 0, 250, 500 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (835697)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (537306)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive